MDF is one of our favorite materials for laser cutting and engraving. We laser cut up to 1″ (25.4mm) thick boards mostly for the interior and sign applications.
From Wikipedia:
Medium-density fiberboard (MDF) is an engineered wood product made by breaking down hardwood or softwood residuals into wood fibres, often in a defibrator, combining it with wax and a resin binder, and forming panels by applying high temperature and pressure.[1] MDF is generally denser than plywood. It is made up of separated fibres, but can be used as a building material similar in application to plywood. It is stronger and much more dense than particle board.[2]
The name derives from the distinction in densities of fibreboard. Large-scale production of MDF began in the 1980s, in both North America and Europe.